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Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase

Human Gb3/CD77 synthase (α1,4-galactosyltransferase) is the only known glycosyltransferase that changes acceptor specificity because of a point mutation. The enzyme, encoded by A4GALT locus, is responsible for biosynthesis of Gal(α1–4)Gal moiety in Gb3 (CD77, P(k) antigen) and P1 glycosphingolipids....

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Bibliografski detalji
Izdano u:Glycoconj J
Glavni autori: Kaczmarek, Radoslaw, Mikolajewicz, Katarzyna, Szymczak, Katarzyna, Duk, Maria, Majorczyk, Edyta, Krop-Watorek, Anna, Buczkowska, Anna, Czerwinski, Marcin
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149393/
https://ncbi.nlm.nih.gov/pubmed/27538840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10719-016-9716-9
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