Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry

The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually promiscuous glycosyltransferase. It synthesizes the Galα1→4Gal linkage on two different glycosphingolipids (GSLs), producing globotriaosylceramide (Gb3, CD77, P(k)) and the P1 antigen. Gb3 is the major receptor for Shiga toxins...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Szymczak-Kulus, Katarzyna, Weidler, Sascha, Bereznicka, Anna, Mikolajczyk, Krzysztof, Kaczmarek, Radoslaw, Bednarz, Bartosz, Zhang, Tao, Urbaniak, Anna, Olczak, Mariusz, Park, Enoch Y., Majorczyk, Edyta, Kapczynska, Katarzyna, Lukasiewicz, Jolanta, Wuhrer, Manfred, Unverzagt, Carlo, Czerwinski, Marcin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949097/
https://ncbi.nlm.nih.gov/pubmed/33460651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100299
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