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Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry
The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually promiscuous glycosyltransferase. It synthesizes the Galα1→4Gal linkage on two different glycosphingolipids (GSLs), producing globotriaosylceramide (Gb3, CD77, P(k)) and the P1 antigen. Gb3 is the major receptor for Shiga toxins...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949097/ https://ncbi.nlm.nih.gov/pubmed/33460651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100299 |
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