Muscleblind proteins regulate alternative splicing

Although the muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), a specific function for these proteins has not been reported. A key feature of the RNA-mediated pathogenesis model for DM is the disrupted splicing of specific pre-mRNA targets. Here we demonstrate that MB...

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Main Authors: Ho, Thai H, Charlet-B, Nicolas, Poulos, Michael G, Singh, Gopal, Swanson, Maurice S, Cooper, Thomas A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514918/
https://ncbi.nlm.nih.gov/pubmed/15257297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600300
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