Muscleblind-Like 2 Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy

The RNA-mediated disease model for myotonic dystrophy (DM) proposes that microsatellite C(C)TG expansions express toxic RNAs which disrupt splicing regulation by altering MBNL1 and CELF1 activities. While this model explains DM manifestations in muscle, less is known about the effects of C(C)UG expr...

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Main Authors: Charizanis, Konstantinos, Lee, Kuang-Yung, Batra, Ranjan, Goodwin, Marianne, Zhang, Chaolin, Yuan, Yuan, Shiue, Lily, Cline, Melissa, Scotti, Marina M., Xia, Guangbin, Kumar, Ashok, Ashizawa, Tetsuo, Clark, H. Brent, Kimura, Takashi, Takahashi, Masanori P., Fujimura, Harutoshi, Jinnai, Kenji, Yoshikawa, Hiroo, Gomes-Pereira, Mário, Gourdon, Geneviève, Sakai, Noriaki, Nishino, Seiji, Foster, Thomas C., Ares, Manuel, Darnell, Robert B., Swanson, Maurice S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418517/
https://ncbi.nlm.nih.gov/pubmed/22884328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.05.029
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