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Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress

Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway. To gain a better understanding of the potential antioxidant roles the BVR enzym...

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Bibliografiske detaljer
Udgivet i:Comp Biochem Physiol C Toxicol Pharmacol
Main Authors: Holowiecki, Andrew, O’Shields, Britton, Jenny, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148680/
https://ncbi.nlm.nih.gov/pubmed/27760386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpc.2016.10.006
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