“Marker of Self” CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors

Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self” CD47, which inhibits macrophage uptake of cells wh...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Sosale, Nisha G, Ivanovska, Irena I, Tsai, Richard K, Swift, Joe, Hsu, Jake W, Alvey, Cory M, Zoltick, Philip W, Discher, Dennis E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148596/
https://ncbi.nlm.nih.gov/pubmed/28053997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.80
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