Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity

Sterol synthesis in fungi is an aerobic process requiring molecular oxygen and, for several cytochrome-mediated reactions, aerobically synthesized heme. Cytochrome b(5) is required for sterol C5-6 desaturation and the encoding gene, CYB5, is nonessential in Saccharomyces cerevisiae. Cyb5p and Ncp1p...

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Hauptverfasser: Rogers, K. M., Pierson, C. A., Culbertson, N. T., Mo, C., Sturm, A. M., Eckstein, J., Barbuch, R., Lees, N. D., Bard, M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514794/
https://ncbi.nlm.nih.gov/pubmed/15328107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3425-3435.2004
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