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Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity
Sterol synthesis in fungi is an aerobic process requiring molecular oxygen and, for several cytochrome-mediated reactions, aerobically synthesized heme. Cytochrome b(5) is required for sterol C5-6 desaturation and the encoding gene, CYB5, is nonessential in Saccharomyces cerevisiae. Cyb5p and Ncp1p...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514794/ https://ncbi.nlm.nih.gov/pubmed/15328107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3425-3435.2004 |
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