SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease

Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were bett...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bermudez, Luiz E., Kolonoski, Peter, Seitz, Lianne E., Petrofsky, Mary, Reynolds, Robert, Wu, Martin, Young, Lowell S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514788/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15328125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.9.3556-3558.2004
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