GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK

The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects responsible r...

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Bibliografiset tiedot
Julkaisussa:J Cell Biol
Päätekijät: Bendre, Shweta, Rondelet, Arnaud, Hall, Conrad, Schmidt, Nadine, Lin, Yu-Chih, Brouhard, Gary J., Bird, Alexander W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2016
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147003/
https://ncbi.nlm.nih.gov/pubmed/27881713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606081
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