GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK

The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects responsible r...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Bendre, Shweta, Rondelet, Arnaud, Hall, Conrad, Schmidt, Nadine, Lin, Yu-Chih, Brouhard, Gary J., Bird, Alexander W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147003/
https://ncbi.nlm.nih.gov/pubmed/27881713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606081
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