Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in t...

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Publicat a:Genome Biol
Autors principals: Demeulemeester, Jonas, Kumar, Parveen, Møller, Elen K., Nord, Silje, Wedge, David C., Peterson, April, Mathiesen, Randi R., Fjelldal, Renathe, Zamani Esteki, Masoud, Theunis, Koen, Fernandez Gallardo, Elia, Grundstad, A. Jason, Borgen, Elin, Baumbusch, Lars O., Børresen-Dale, Anne-Lise, White, Kevin P., Kristensen, Vessela N., Van Loo, Peter, Voet, Thierry, Naume, Bjørn
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146893/
https://ncbi.nlm.nih.gov/pubmed/27931250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1109-7
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