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Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O(2) regulation of erythrocyte properties

Functional studies have shown that the oxygenation state of the erythrocyte regulates many important pathways, including glucose metabolism, membrane mechanical stability, and cellular adenosine triphosphate (ATP) release. Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds avidly and reversibly...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chu, Haiyan, McKenna, Mary M., Krump, Nathan A., Zheng, Suilan, Mendelsohn, Laurel, Thein, Swee Lay, Garrett, Lisa J., Bodine, David M., Low, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146745/
https://ncbi.nlm.nih.gov/pubmed/27688804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-692079
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