Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O(2) regulation of erythrocyte properties

Functional studies have shown that the oxygenation state of the erythrocyte regulates many important pathways, including glucose metabolism, membrane mechanical stability, and cellular adenosine triphosphate (ATP) release. Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds avidly and reversibly...

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Bibliographic Details
Published in:Blood
Main Authors: Chu, Haiyan, McKenna, Mary M., Krump, Nathan A., Zheng, Suilan, Mendelsohn, Laurel, Thein, Swee Lay, Garrett, Lisa J., Bodine, David M., Low, Philip S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2016
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146745/
https://ncbi.nlm.nih.gov/pubmed/27688804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-692079
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