Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O(2) regulation of erythrocyte properties

Functional studies have shown that the oxygenation state of the erythrocyte regulates many important pathways, including glucose metabolism, membrane mechanical stability, and cellular adenosine triphosphate (ATP) release. Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds avidly and reversibly...

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Pubblicato in:Blood
Autori principali: Chu, Haiyan, McKenna, Mary M., Krump, Nathan A., Zheng, Suilan, Mendelsohn, Laurel, Thein, Swee Lay, Garrett, Lisa J., Bodine, David M., Low, Philip S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146745/
https://ncbi.nlm.nih.gov/pubmed/27688804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-692079
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