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Reassessing random-coil statistics in unfolded proteins

The Gaussian-distributed random coil has been the dominant model for denatured proteins since the 1950s, and it has long been interpreted to mean that proteins are featureless, statistical coils in 6 M guanidinium chloride. Here, we demonstrate that random-coil statistics are not a unique signature...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Fitzkee, Nicholas C., Rose, George D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514656/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15314216/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404236101
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