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Steric restrictions in protein folding: An α-helix cannot be followed by a contiguous β-strand

Using only hard-sphere repulsion, we investigated short polyalanyl chains for the presence of sterically imposed conformational constraints beyond the dipeptide level. We found that a central residue in a helical peptide cannot adopt dihedral angles from strand regions without encountering a steric...

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Detalhes bibliográficos
Main Authors: Fitzkee, Nicholas C., Rose, George D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286724/
https://ncbi.nlm.nih.gov/pubmed/14767081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03503304
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