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The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α(1)-Antitrypsin
α(1)-Antitrypsin, the archetypal member of the serpin superfamily, is a metastable protein prone to polymerization when exposed to stressors such as elevated temperature, low denaturant concentrations or through the presence of deleterious mutations which, in a physiological context, are often assoc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558512/ https://ncbi.nlm.nih.gov/pubmed/23382962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054766 |
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