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Reassessing random-coil statistics in unfolded proteins

The Gaussian-distributed random coil has been the dominant model for denatured proteins since the 1950s, and it has long been interpreted to mean that proteins are featureless, statistical coils in 6 M guanidinium chloride. Here, we demonstrate that random-coil statistics are not a unique signature...

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Main Authors: Fitzkee, Nicholas C., Rose, George D.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC514656/
https://ncbi.nlm.nih.gov/pubmed/15314216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404236101
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