Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-defic...

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Detaylı Bibliyografya
Asıl Yazarlar: Chan, Keith Syson, Sano, Shigetoshi, Kiguchi, Kaoru, Anders, Joanne, Komazawa, Nobuyasu, Takeda, Junji, DiGiovanni, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2004
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC514583/
https://ncbi.nlm.nih.gov/pubmed/15343391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421032
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