Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-defic...

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Publicat a:J Clin Invest
Autors principals: Chan, Keith Syson, Sano, Shigetoshi, Kiguchi, Kaoru, Anders, Joanne, Komazawa, Nobuyasu, Takeda, Junji, DiGiovanni, John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2004
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Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514583/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15343391/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI21032
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