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Targeted disruption of Stat3 reveals a major role for follicular stem cells in skin tumor initiation
The initiation stage of mouse skin carcinogenesis involves induction of mutations in keratinocyte stem cells (KSCs), which confers a selective growth advantage allowing clonal expansion during tumor promotion. Targeted disruption of Stat3 in bulge region keratinocyte stem cells was achieved by treat...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4043290/ https://ncbi.nlm.nih.gov/pubmed/19738054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1180 |
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