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Targeted disruption of Stat3 reveals a major role for follicular stem cells in skin tumor initiation

The initiation stage of mouse skin carcinogenesis involves induction of mutations in keratinocyte stem cells (KSCs), which confers a selective growth advantage allowing clonal expansion during tumor promotion. Targeted disruption of Stat3 in bulge region keratinocyte stem cells was achieved by treat...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Kim, Dae Joon, Kataoka, Ken, Rao, Dharanija, Kiguchi, Kaoru, Cotsarelis, George, DiGiovanni, John
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043290/
https://ncbi.nlm.nih.gov/pubmed/19738054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1180
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