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Endotoxin leads to rapid subcellular re-localization of hepatic RXRα: A novel mechanism for reduced hepatic gene expression in inflammation

BACKGROUND: Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase response (APR). Retinoid X receptor α (RXRα), the most highly expressed RXR isoform...

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Main Authors: Ghose, Romi, Zimmerman, Tracy L, Thevananther, Sundararajah, Karpen, Saul J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC514570/
https://ncbi.nlm.nih.gov/pubmed/15312234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-1336-2-4
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