Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

Mutations in the gene encoding the KMT2D (also called MLL2) methyltransferase are highly recurrent and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). However, the functional consequences of KMT2D mutations and their role in lymphomagenesis are...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Zhang, Jiyuan, Dominguez-Sola, David, Hussein, Shafinaz, Lee, Ji-Eun, Holmes, Antony B., Bansal, Mukesh, Vlasevska, Sofija, Mo, Tongwei, Tang, Hongyan, Basso, Katia, Ge, Kai, Dalla-Favera, Riccardo, Pasqualucci, Laura
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145002/
https://ncbi.nlm.nih.gov/pubmed/26366712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3940
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