Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). Here, we examined the relationship between these two enzymes in germinal center (GC) B cells, the normal counterpart...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Meyer, Stefanie N., Scuoppo, Claudio, Vlasevska, Sofija, Bal, Elodie, Holmes, Antony B., Holloman, Mara, Garcia-Ibanez, Laura, Nataraj, Sarah, Duval, Romain, Vantrimpont, Thomas, Basso, Katia, Brooks, Nigel, Dalla-Favera, Riccardo, Pasqualucci, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362711/
https://ncbi.nlm.nih.gov/pubmed/31519498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.08.006
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