Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3

Kelch-like 3 (KLHL3) is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. Mutations in KLHL3 cause constitutively increased renal salt reabsorption and impaired K(+) secretion, resulting in hypertension and hyperkal...

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Publicado en:Biochem Biophys Res Commun
Autores principales: Ishizawa, Kenichi, Xu, Ning, Loffing, Johannes, Lifton, Richard P., Fujita, Toshiro, Uchida, Shunya, Shibata, Shigeru
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144580/
https://ncbi.nlm.nih.gov/pubmed/27942049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.10.127
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