Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice

BACKGROUND: Mechanisms underlying the frequent association between salt-sensitive hypertension and type 2 diabetes remain obscure. We previously found that protein kinase C (PKC) activation phosphorylates Kelch-like 3 (KLHL3), an E3 ubiquitin ligase component, at serine 433. We investigated whether...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Ishizawa, Kenichi, Wang, Qin, Li, Jinping, Xu, Ning, Nemoto, Yoshikazu, Morimoto, Chikayuki, Fujii, Wataru, Tamura, Yoshifuru, Fujigaki, Yoshihide, Tsukamoto, Kazuhisa, Fujita, Toshiro, Uchida, Shunya, Shibata, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493993/
https://ncbi.nlm.nih.gov/pubmed/30914436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070703
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