Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling

Calcineurin is a calcium/calmodulin-regulated phosphatase known for its role in activation of T cells following engagement of the T cell receptor. Calcineurin inhibitors (CNIs) are widely used as immunosuppressive agents; common adverse effects of CNIs are hypertension and hyperkalemia. While previo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ishizawa, Kenichi, Wang, Qin, Li, Jinping, Yamazaki, Osamu, Tamura, Yoshifuru, Fujigaki, Yoshihide, Uchida, Shunya, Lifton, Richard P., Shibata, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386661/
https://ncbi.nlm.nih.gov/pubmed/30718414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817281116
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