Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo
IMP dehydrogenase (IMPDH) is the rate-limiting enzyme for de novo GMP synthesis. Its activity is correlated with cell growth, and it is the target of a number of proven and experimental drug therapies including mycophenolic acid (MPA). MPA inhibits the enzyme by trapping a covalent nucleotide-enzyme...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15292516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403341101 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|