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Mutagen-induced resistance to mycophenolic acid in hamster cells can be associated with increased inosine 5'-phosphate dehydrogenase activity.

Cell variants resistant to the cytotoxic effect of mycophenolic acid, an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC 1.2.1.14), were selected by a one-step procedure from Chinese hamster V79 cells. The frequency of these variants was increased in a dose-dependent manner after treatme...

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Bibliografiske detaljer
Main Authors: Huberman, E, McKeown, C K, Friedman, J
Format: Artigo
Sprog:Inglês
Udgivet: 1981
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC319518/
https://ncbi.nlm.nih.gov/pubmed/6114490
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