Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo
IMP dehydrogenase (IMPDH) is the rate-limiting enzyme for de novo GMP synthesis. Its activity is correlated with cell growth, and it is the target of a number of proven and experimental drug therapies including mycophenolic acid (MPA). MPA inhibits the enzyme by trapping a covalent nucleotide-enzyme...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15292516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403341101 |
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