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Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

Non-homologous end joining (NHEJ) is one of the primary pathways for the repair of ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) in mammalian cells. Proteins required for NHEJ include the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), Ku, XRCC4 and DNA ligase IV....

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Autori principali: Block, Wesley D., Yu, Yaping, Merkle, Dennis, Gifford, Jessica L., Ding, Qi, Meek, Katheryn, Lees-Miller, Susan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC514382/
https://ncbi.nlm.nih.gov/pubmed/15314205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh761
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