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Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine

Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR). In contrast, caffeine has been reported to have...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Block, Wesley D., Merkle, Dennis, Meek, Katheryn, Lees-Miller, Susan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC390360/
https://ncbi.nlm.nih.gov/pubmed/15060176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh508
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