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Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation

As its name implies, the DNA dependent protein kinase (DNA-PK) requires DNA double-stranded ends for enzymatic activation. Here, I demonstrate that hairpinned DNA ends are ineffective for activating the kinase toward many of its well-studied substrates (p53, XRCC4, XLF, HSP90). However, hairpinned D...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
1. Verfasser: Meek, Katheryn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498359/
https://ncbi.nlm.nih.gov/pubmed/32716029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa614
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