Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)(n) is mediated by homolog-conserved domains in three members of the hnRNP family

Hairpin or tetrahelical structures formed by a d(CGG)(n) sequence in the FMR1 gene are thought to promote expansion of the repeat tract. Subsequent to this expansion FMR1 is silenced and fragile X syndrome ensues. The injurious effects of d(CGG)(n) secondary structures may potentially be countered b...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Khateb, Samer, Weisman-Shomer, Pnina, Hershco, Inbal, Loeb, Lawrence A., Fry, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2004
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Articles
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514371/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15302914/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh745
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