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Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)(n) is mediated by homolog-conserved domains in three members of the hnRNP family
Hairpin or tetrahelical structures formed by a d(CGG)(n) sequence in the FMR1 gene are thought to promote expansion of the repeat tract. Subsequent to this expansion FMR1 is silenced and fragile X syndrome ensues. The injurious effects of d(CGG)(n) secondary structures may potentially be countered b...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514371/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15302914/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh745 |
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