Carregant...

Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)(n) is mediated by homolog-conserved domains in three members of the hnRNP family

Hairpin or tetrahelical structures formed by a d(CGG)(n) sequence in the FMR1 gene are thought to promote expansion of the repeat tract. Subsequent to this expansion FMR1 is silenced and fragile X syndrome ensues. The injurious effects of d(CGG)(n) secondary structures may potentially be countered b...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Khateb, Samer, Weisman-Shomer, Pnina, Hershco, Inbal, Loeb, Lawrence A., Fry, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC514371/
https://ncbi.nlm.nih.gov/pubmed/15302914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh745
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!