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The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)(n)

Fragile X syndrome, the most common cause of inherited mental retardation, is instigated by dynamic expansion of a d(CGG) trinucleotide repeat in the 5′-untranslated region of the first exon of the FMR1 gene, resulting in its silencing. The expanded d(CGG)(n) tract readily folds into hairpin and tet...

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Detalhes bibliográficos
Main Authors: Weisman-Shomer, Pnina, Cohen, Esther, Hershco, Inbal, Khateb, Samer, Wolfovitz-Barchad, Orit, Hurley, Laurence H., Fry, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165968/
https://ncbi.nlm.nih.gov/pubmed/12853612
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