The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)(n)

Fragile X syndrome, the most common cause of inherited mental retardation, is instigated by dynamic expansion of a d(CGG) trinucleotide repeat in the 5′-untranslated region of the first exon of the FMR1 gene, resulting in its silencing. The expanded d(CGG)(n) tract readily folds into hairpin and tet...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Weisman-Shomer, Pnina, Cohen, Esther, Hershco, Inbal, Khateb, Samer, Wolfovitz-Barchad, Orit, Hurley, Laurence H., Fry, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg453
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