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Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)(n) is mediated by homolog-conserved domains in three members of the hnRNP family
Hairpin or tetrahelical structures formed by a d(CGG)(n) sequence in the FMR1 gene are thought to promote expansion of the repeat tract. Subsequent to this expansion FMR1 is silenced and fragile X syndrome ensues. The injurious effects of d(CGG)(n) secondary structures may potentially be countered b...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2004
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514371/ https://ncbi.nlm.nih.gov/pubmed/15302914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh745 |
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