Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease

Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress signalling, specifically to the activation...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Celardo, I, Costa, A C, Lehmann, S, Jones, C, Wood, N, Mencacci, N E, Mallucci, G R, Loh, S H Y, Martins, L M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143399/
https://ncbi.nlm.nih.gov/pubmed/27336715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.173
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