Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease

Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress signalling, specifically to the activation...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Celardo, I, Costa, A C, Lehmann, S, Jones, C, Wood, N, Mencacci, N E, Mallucci, G R, Loh, S H Y, Martins, L M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143399/
https://ncbi.nlm.nih.gov/pubmed/27336715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.173
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