PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitoc...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Quinn, Peter M. J., Moreira, Paula I., Ambrósio, António Francisco, Alves, C. Henrique
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654589/
https://ncbi.nlm.nih.gov/pubmed/33168089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01062-w
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