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A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification
The gene ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion. It arose on the human evolutionary lineage by partial duplication of ARHGAP11A, which encodes a Rho guanosine triphosphatase–activating protein (RhoGAP). However, a lack of 55 nucleotides in ARHGAP11...
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| Veröffentlicht in: | Sci Adv |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142801/ https://ncbi.nlm.nih.gov/pubmed/27957544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601941 |
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