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A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification

The gene ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion. It arose on the human evolutionary lineage by partial duplication of ARHGAP11A, which encodes a Rho guanosine triphosphatase–activating protein (RhoGAP). However, a lack of 55 nucleotides in ARHGAP11...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Florio, Marta, Namba, Takashi, Pääbo, Svante, Hiller, Michael, Huttner, Wieland B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142801/
https://ncbi.nlm.nih.gov/pubmed/27957544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601941
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