Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer

Generating Tier 2 HIV neutralizing antibody (nAb) responses by immunization remains a challenging problem, and the immunological barriers to induction of such responses with Env immunogens remain unclear. Here, some rhesus monkeys developed autologous Tier 2 nAbs upon HIV Env trimer immunization (SO...

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Publicado no:Cell Rep
Main Authors: Havenar-Daughton, Colin, Carnathan, Diane G., Torrents de la Peña, Alba, Pauthner, Matthias, Briney, Bryan, Reiss, Samantha M., Wood, Jennifer S., Kaushik, Kirti, van Gils, Marit J., Rosales, Sandy, van der Woude, Patricia, Locci, Michela, Le, Khoa M., de Taeye, Steven W., Sok, Devin, Rasheed Mohammed, Ata Ur, Huang, Jessica, Gumber, Sanjeev, Garcia, Anapatricia, Kasturi, Sudhir P., Pulendran, Bali, Moore, John P., Ahmed, Rafi, Seumois, Grégory, Burton, Dennis R., Sanders, Rogier W., Silvestri, Guido, Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142765/
https://ncbi.nlm.nih.gov/pubmed/27880897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.085
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