TruePrime is a novel method for whole-genome amplification from single cells based on TthPrimPol

Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimP...

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Publicat a:Nat Commun
Autors principals: Picher, Ángel J., Budeus, Bettina, Wafzig, Oliver, Krüger, Carola, García-Gómez, Sara, Martínez-Jiménez, María I., Díaz-Talavera, Alberto, Weber, Daniela, Blanco, Luis, Schneider, Armin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141293/
https://ncbi.nlm.nih.gov/pubmed/27897270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13296
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