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The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming

Human PrimPol is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication. PrimPol contains an Archeal-Eukaryotic Primases (AEP) core followed by a C-terminal Zn finger-containing domain (ZnFD), that is exclusively...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Martínez-Jiménez, María I, Calvo, Patricia A, García-Gómez, Sara, Guerra-González, Susana, Blanco, Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934617/
https://ncbi.nlm.nih.gov/pubmed/29608762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky230
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