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The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming
Human PrimPol is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication. PrimPol contains an Archeal-Eukaryotic Primases (AEP) core followed by a C-terminal Zn finger-containing domain (ZnFD), that is exclusively...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5934617/ https://ncbi.nlm.nih.gov/pubmed/29608762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky230 |
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