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Identification of CASZ1 nuclear export signal (NES) reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma

As a transcription factor, localization to the nucleus and the recruitment of co-factors to regulate gene transcription is essential. Nuclear localization and nucleosome remodeling and histone deacetylase (NuRD) complex binding are required for the zinc finger transcription factor CASZ1 to function...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Liu, Zhihui, Lam, Norris, Wang, Evelyn, Virden, Ryan A., Pawel, Bruce, Attiyeh, Edward F., Maris, John M., Thiele, Carol J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140774/
https://ncbi.nlm.nih.gov/pubmed/27270431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.179
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