EZH2 mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3 and NGFR

Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but the basis for these characteristics remains unknown. In this study, we show that upregulation of the Polycomb complex histone methytransferase EZH2, which limits...

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Autori principali: Wang, Chunxi, Liu, Zhihui, Woo, Chan-Wook, Li, Zhijie, Wang, Lifeng, Wei, Jun S., Marquez, Victor E., Bates, Susan E., Jin, Qihuang, Khan, Javed, Ge, Kai, Thiele, Carol J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487161/
https://ncbi.nlm.nih.gov/pubmed/22068036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0961
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