The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer

In gastric cancer, a new epigenetic mechanism of tumour suppressor loss has been suggested where the histone methyltransferase enhancer of zeste homolog 2 (EZH2) is responsible for loss of expression of RUNX3. This is consistent with EZH2 upregulation in multiple cancer types being associated with p...

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Detalhes bibliográficos
Main Authors: Kodach, Liudmila L., Jacobs, Rutger J., Heijmans, Jarom, van Noesel, Carel J.M., Langers, Alexandra M.J., Verspaget, Hein W., Hommes, Daniel W., Offerhaus, G.Johan A., van den Brink, Gijs R., Hardwick, James C.H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930806/
https://ncbi.nlm.nih.gov/pubmed/20631058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq147
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