Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as well as in those with established disease who receive islet replacement or regeneration therapy. Because functio...

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Publicado no:Nat Med
Main Authors: Babon, Jenny Aurielle B, DeNicola, Megan E, Blodgett, David M, Crèvecoeur, Inne, Buttrick, Thomas S, Maehr, René, Bottino, Rita, Naji, Ali, Kaddis, John, Elyaman, Wassim, James, Eddie A, Haliyur, Rachana, Brissova, Marcela, Overbergh, Lut, Mathieu, Chantal, Delong, Thomas, Haskins, Kathryn, Pugliese, Alberto, Campbell-Thompson, Martha, Mathews, Clayton, Atkinson, Mark A, Powers, Alvin C, Harlan, David M, Kent, Sally C
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140746/
https://ncbi.nlm.nih.gov/pubmed/27798614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4203
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